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Study material: Venous blood
Response time (working day): 14
The test is done on an empty stomach: no
Home call service: YesB-type natriuretic peptide (NT-proBNP) is a biomarker that is released by the ventricles of the heart in response to their excessive load and stretch. Its determination is used to diagnose heart failure, assess its severity, and monitor the effectiveness of treatment. Elevated levels of NT-proBNP often indicate heart failure, although the result must be interpreted in conjunction with the patient's clinical condition and other studies.
B-type natriuretic peptide N-terminal pro B-type natriuretic peptide is a precursor to a hormone produced by the heart that indicates left atrial workload.
Heart failure is a condition whose development is associated with at least one of the following symptoms/signs: increased serum natriuretic factor levels, hemodynamic and/or imaging evidence of pulmonary or congestive heart failure, at rest or during exercise.
Diagnosing heart failure at an early stage is often difficult, because the symptoms expressed at this stage: dyspnea (shortness of breath), weakness and peripheral edema - are non-specific signs. Diagnosis is even more complicated in elderly and obese people. Ultrasound examination of the heart is the most common method at this time. Cardiac biomarkers provide an opportunity to diagnose the disease at an early stage.
PRO-BNP breaks down into biologically active form – BNP-B type natriuretic peptide and inactive NT-probnp.
It has been established that BNP (and therefore B-type natriuretic peptide) correlates with left ventricular failure.
The heart's pump function is quantified by estimating the left ventricular ejection fraction. It is defined as the ratio of the stroke volume at the end of diastole (relaxation of the ventricle) to the volume of blood retained in the left ventricle.
A normal ejection fraction is 50-65%, and less than 50% is indicative of heart damage.
Preliminary preparation:it is not necessary
Study sample:Venous blood
Determination of N-terminal pro-B-type natriuretic peptide is important in the diagnostics of conditions such as:
Determination of natriuretic peptide, including NT-proBNP, is a biomarker for the assessment of heart failure. An increase in indicators indicates an increase in heart failure and an increase in the risk of death.
NT-proBNP can be increased not only in heart failure, but also:
NT-proBNP is a very sensitive but non-specific marker, so its evaluation must be performed by a physician, along with the clinical picture and additional studies (e.g., echocardiography).
The clinical significance of natriuretic peptides has long been established. They are a family of molecules represented by ANP-A type (ventricle), BNP-B type (brain) and CNP-C type natriuretic peptides. Their role is to maintain the homeostasis of circulating blood. ANP and BNP affect water-electrolyte balance.
The A-type natriuretic peptide ANP is rapidly released into the circulation, whereas the B-type is produced as precursors (pre-pro-BNP and pro-BNP) and released from the ventricular myocardium after prolonged parietal (ventricular wall) stress. (The parietal stress is the force against the heart cells).
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