Apolipoprotein A1 | Laboratory research

General Information

Apolipoproteins are complex protein components and are used to assess the risk of coronary heart disease.

Apolipoprotein A (APO-A) is the main component (90%) of high-density lipoproteins (HDL).

Apolipoprotein B (APO-B) is the main component of low-density lipoproteins (LDL) and regulates cholesterol synthesis and metabolism.

Of the apolipoproteins, APO-A1 and APO-B concentrations are the most stable and best reflect the relationship with the severity of cardiovascular diseases.

At present, there is an opinion that the APO-A1 level in the blood reflects the risk of coronary diseases better than HDL-cholesterol.

APO-A1/APO-B ratio is more sensitive than HDL/LDL or HDL/triglyceride ratio.

When is the survey conducted?

The purpose of the study is to assess the risk of developing coronary heart disease in patients:

• Cholesterol limit value
• An increase in LDL/HDL ratio against a normal total cholesterol level
• People with a family history of cardiovascular disease, with normal cholesterol levels
• Patients with triglyceridemia who have risk factors for the development of coronary disease
• Congenital cases of dyslipidemia (Tangier disease), with hereditary deficiency of HDL and cholesterol accumulation in various organs, especially in the reticulo-endothelial system - liver, spleen, lymph nodes and glands, both in children and adults.

Addition of the patient: The research should be done on an empty stomach, 12-14 hours after the last meal

Material for examination: Venous blood

Referral norms

APO-A1

APO-B

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APO A-1/APO B ratio

Interpretation of results

APO-A1 research is influenced by the following factors:

drugs

Causes an increase in: carbamazepine, furosemide, oral contraceptives, phenobarbital, phenytoin, steroids, gemfibrozil, clofibrate

Lowering of the index causes: lovastatin

The following factors influence the APO-B study:

drugs

An increase in the rate is caused by: amiodarone, atenolol, cyclosporine, estrogens, furosemide, metoprolol, phenobarbital, radioactive iodine, androgens (anabolic steroids), chlorthialidone, gemfibrozil, isotretinoin, levonorgestrel, oral contraceptives, simvastatin, stanozolol,

Decreases: captopril, indomethacin, interferon, ketoconazole, neomycin, niacin, nifedipine, prazosin, prednisolone, tacrolimus, cholestyramine, colestipol, estrogens (post-menopausal), simvastatin, lovastatin, pravastatin, ketoconazole, neomycin, niacin

Very rarely, in gamopathy, especially Waldenström's disease, the test may give a false answer.