Antistreptolysin O (ASLO)

Streptolysin is a hemolytic toxin produced by group A streptococcus. In infected patients, streptolysin acts as an antigen against which the body produces specific antibodies – O antistreptolysins. An increase in the concentration of antistreptolysin antibodies indicates the body's sensitization to streptococcal antigens. The increase in the concentration of ASL-O begins 1 week after the diagnostics of streptococcal infection and its level reaches a maximum in 2-4 weeks. In the absence of complications or recurrence of infection, the level of ASL-O returns to normal after 6-12 months.

ASL-O (antistreptolysin-O) A persistent increase in the level increases the risk of developing rheumatoid diseases. During the recovery period, the indicator decreases compared to the acute period. Serial testing (with an interval of approximately 1-2 weeks) has the maximum diagnostic and prognostic value. ASL-O titer can also be increased in healthy carriers of streptococci.

When to take an antistreptolysin O test?

• Confirmation of the effect of streptococcal streptolysin;
• Diagnosis of conditions associated with streptococcal infections: acute rheumatoid arthritis, glomerulonephritis, endocarditis, gout
• Regular monitoring of patients with acute rheumatoid arthritis (every 2-4 weeks).

Research material

Venous blood

Possible interpretation of the results

Concentrations of antistreptolysin-O increase:

• Rheumatism;
• Streptococcal infections;
• Acute diffuse glomerulonephritis.

Resources

https://spravochnik.synevo.ua/ru/klinicheskaia-himia/antistreptolysin-o.html