Antistreptodornase B | Antibodies

General Information

Group A streptococci cause a wide range of infections (respiratory system, skin and subcutaneous tissue, systemic inflammation, pharyngitis, sepsis, etc.).

Streptodornase, or streptococcal deoxyribonuclease, is an enzyme that depolymerizes DNA (converts it into simpler structural units) and has antigenic properties.

There are 4 types of streptodornase (A, B, C, D), of which streptodornase B is produced in the largest quantities by pyogenic streptococcus.

Antibody titers appear 1-2 weeks after acute infection and peak at 3-6 weeks. If antibody levels remain high for 6 weeks, reinfection should be suspected.

Antibodies against streptodornase B develop in 85-80% of group A streptococcal infections, and antibodies persist for 2-3 months after infection.

Antibodies against streptodornase remain in the blood for a long time, which allows us to detect further complications of streptococcal infection: rheumatoid chorea, etc.

When is the survey conducted?

When diagnosing past streptococcal infection

Preparation of the patient: it is not necessary

Material for examination: Venous blood

Interpretation of results

Anti-streptodornase antibody testing is a sensitive method for diagnosing post-streptococcal glomerulonephritis and necrotizing fasciitis. If anti-streptodornase antibody and anti-streptolysin antibody levels are negative on repeat testing, this means that the patient's symptoms are not related to post-streptococcal complications.

Antibiotic therapy administered affects the number of streptodornase antibodies.