Cardiolipin Antibodies IgG

General Information

Cardiolipin IgG antibodiesare autoantibodies directed against cardiolipin and related phospholipids. Their detection is used Antiphospholipid Syndromein the diagnostics of and assessment of the risk of thrombosis, recurrent miscarriage, and other pregnancy complications. The results of the study should be evaluated in conjunction with clinical data and other antiphospholipid antibodies (anti-β2 glycoprotein I, lupus anticoagulant).

Cardiolipin IgG antibodies

Cardiolipin IgG autoantibodies are antibodies associated with arterial and venous thrombosis and are characteristic of primary antiphospholipid syndrome and systemic lupus erythematosus. (Cardiolipin antibodies are often, but not always, the cause of lupus anticoagulant activation.)

Anti-cardiolipin antibodies are also found in patients who do not have systemic lupus erythematosus, but have unspecified arterial-venous thrombosis, myocardial infarction, stroke, spontaneous abortions.

Anticardiolipin antibodies are one group of antiphospholipid antibodies. The discovery of these antibodies led to the formation of a new disease called antiphospholipid syndrome. Antiphospholipid syndrome is characterized by a wide variety of symptoms. Antiphospholipid antibodies have also been found in some infections and cancers. In phospholipid syndrome, B2-glycoprotein-1 autoantibodies are often associated with anticardiolipin antibodies. Anticardiolipin antibodies are represented by IgM, IgG and IgA classes. IgG is the most common form.

Anticardiolipins may be positive in patients without obvious signs of thrombosis.