Aldolaza | Laboratory research

General Information

Aldolase is an enzyme that is involved in the conversion of sugars into energy. Aldolase is found in the largest amounts in liver and muscle cells, so when these cells are damaged, the concentration of aldolase in the blood increases.

When is the survey conducted?

In myasthenia (muscle weakness), myalgia (muscle pain), and myodystrophies (degenerative muscle diseases), serum aldolase levels are measured along with other laboratory parameters.

How to prepare for the test?

The test is performed without fasting. It is recommended to limit physical activity before taking the test sample. It is necessary to provide the laboratory with information about the medications you are taking at the time of sample collection. The issue of stopping medication before the test is decided by your treating physician.

Interpretation of results

In progressive muscular dystrophies, the aldolase level increases 10-15 times,

Aldolase activity is significantly increased in hepatitis, liver diseases of various etiologies, liver carcinomas, myocardial infarction, hemorrhagic pancreatitis, alcohol intoxication, and some types of neoplasia.

In viral hepatitis, serum aldolase activity increases approximately 20-fold along with alanine aminotransferase (ALT).

In inflammatory myopathies, simultaneous determination of aldolase and creatinine allows us to monitor the effect of treatment with steroidal anti-inflammatory drugs.

During myocardial infarction, serum aldolase levels gradually increase, along with alanine aminotransferase (AST).

Taking some medications changes the aldolase level.

Aldolase levels increase when taking the following medications:: Corticosteroids, diclofenac, itraconazole, lovastatin, niacin, simvastatin, thiabendazole, vasopressin, and others.

Aldolase levels decrease when taking the following medications::  Probucol, phenothiazines.