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Albumin Is a non-glycosylated protein that is synthesized by liver parenchymal cells in an amount of 12-15g per day. It makes up about 60% of the total protein. Plasma albumin is mainly responsible for maintaining oncological pressure and also participates in the transport of various compounds (free fatty acids, bilirubin, hormones, metal ions and drugs), therefore the reduction of albumin concentration in the blood has a significant impact on the pharmacokinetics of drugs. Albumin is also a protein reserve in the body.
Elevated albumin levels:
Dehydration syndrome (infectious diseases (cholera), extensive burns, severe injuries).
Decreased albumin levels:
Hypoalbuminemia (low albumin levels) is caused by several factors: impaired synthesis due to liver disease (primary) or decreased protein intake (secondary), increased catabolism due to tissue damage and inflammation, amino acid malabsorption, and increased renal excretion (eg, nephrotic syndrome).
Serum albumin has a half-life of 18-20 days, this period is reduced in conditions of increased catabolism: in case of severe infections, bleeding, surgical interventions, loss of protein in case of impaired renal, gastrointestinal and skin function. Thus, albumin is considered an "negative" reactant of the acute phase (its concentration decreases in response to acute infectious and inflammatory processes).
Albumin is also an indicator of the general nutritional status of the body, especially in older people who have various chronic diseases. By determining albumin levels, it is possible to monitor a patient's nutrition and it is an excellent test for assessing liver function.
Albumin levels below 2.0-2.5 g / dL associated with nephrotic syndrome, liver cirrhosis, or protein-lost enteropathy may cause edema.
Fasting is recommended for the test.
It is recommended to limit alcohol intake, smoking and strenuous physical activity for at least 12 hours before the test.
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