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Albumin Is a non-glycosylated protein that is synthesized by liver parenchymal cells in an amount of 12-15g per day. It makes up about 60% of the total protein. Plasma albumin is mainly responsible for maintaining oncological pressure and also participates in the transport of various compounds (free fatty acids, bilirubin, hormones, metal ions and drugs), therefore the reduction of albumin concentration in the blood has a significant impact on the pharmacokinetics of drugs. Albumin is also a protein reserve in the body.
Elevated albumin levels:
Dehydration syndrome (infectious diseases (cholera), extensive burns, severe injuries).
Decreased albumin levels:
Hypoalbuminemia (low albumin levels) is caused by several factors: impaired synthesis due to liver disease (primary) or decreased protein intake (secondary), increased catabolism due to tissue damage and inflammation, amino acid malabsorption, and increased renal excretion (eg, nephrotic syndrome).
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