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Albumin - Non-glycated protein, is an important component of blood, cerebrospinal fluid and urine.
Normally, the glomerular membrane of the kidney prevents the passage of albumin from the blood to the glomerular filtrate, causing very small amounts of albumin to be found in the urine. However, abnormal loss of urinary albumin occurs in patients with kidney disease.
For several reasons, to assess renal impairment in adults, the determination of albuminuria over proteinuria (total protein content in urine) is preferred:
Is albuminous Can be found:
The interpretation of the results takes into account the following situations that can cause transient albuminuria: urinary tract infections, hematuria, intense physical exertion, pregnancy, fever, inflammation
Albuminuria is an early marker of glomerular disease, including diabetic glomerulosclerosis, where it usually precedes a reduction in glomerular filtration rate. It is also a marker of hypertensive glomerulosclerosis, but in this case albuminuria develops after a decrease in glomerular filtration rate.
Determination of urinary albumin is recommended to assess glomerular protein loss in adults. The test allows for early detection and monitoring of kidney disease. Determination of urinary albumin is a more sensitive and specific means of detecting changes in glomerular permeability compared to determination of total urinary protein.
Albuminuria is often associated with hypertension, obesity, and vascular disease, conditions in which underlying renal disease may not be apparent.
It is important to note that albumin excretion is characterized by significant biological variability and may be increased due to various physiological and pathological factors. Therefore, it is recommended to confirm the increased values of albumin excretion by 24-hour urine test.
It is recommended to refrain from physical activity for at least 12 hours before the test.
24-hour urine. At 7 o'clock in the morning the patient urinates and does not store this urine, and during the next urination he collects the whole volume of urine in a plastic container (2-3 liter urine container) until 7 o'clock in the morning of the next day (24 hours); The patient should transfer 100 ml of urine from this container (e.g. with a syringe) to a disposable plastic cup for urine and should be stored at 2-8 ° C before the test (1-1,5 h).
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