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Alanine aminotransferase (ALT)

Name: Alanine aminotransferase (ALT)
Brand: სინევო
SKU: 1042
Price: 13.5 GEL
Availability: InStock
Rating: 5 (1 reviews)

Known as: alanine aminotransferase

SKU: 1042

Original price was: ₾15.00.Current price is: ₾13.50.

Study material: Venous blood

Response time (working day): 1

The test is done on an empty stomach: Yes

Home call service: Yes

Country: Georgia

Laboratories❯

General Information

ALT - alanine aminotransferase Or glutampiruvat transaminase (TGP) is an enzyme that belongs to the class of transferases. It is mainly found in the liver (hepatocyte cytosol) and to a lesser extent in the kidneys, myocardium, skeletal muscle, and pancreas.

When hepatocytes are damaged as a result of an infectious or toxic process, the serum ALT concentration increases.

ALT is a more specific indicator of liver damage than AST (aspartate aminotransferase). It increases even with minimal liver damage, before the onset of symptoms and signs of the disease.

Elevated serum ALT is rare in diseases of other organs - e.g. In muscle lesions, rhabdomyolysis, polymyositis, and dermatomyositis, but in these cases serum creatine phosphokinase is also increased.

ALT values do not directly determine the severity of liver damage, it is better to monitor the indicator in dynamics (several times during the course of the disease).

When should we take the test?

For prophylaxis: The AST test may be part of a general assessment of your health, for example, part of a "prophylactic examination profile";
Diagnosis of acute viral hepatitis caused by hepatitis A, B, C, E viruses;
Other acute viral hepatitis - e.g. EBV (Ebstein-Barr virus) and CMV (cytomegalovirus) infections;
Dynamic monitoring of the clinical course of acute hepatitis;
Dynamic monitoring of the treatment effect of acute hepatitis;
Diagnosis of liver and biliary tract diseases;
Diagnosis of pancreatic diseases;
Differential diagnostics of hemolytic hepatic jaundice.

Usually, along with ALT, AST (aspartate aminotransferase) is also defined, as well as cholestasis enzymes - ALP (alkaline phosphatase), GGT (gammaglutamyltranspeptidase, gammaglutamyltransferase), as well as whole and direct bilirubin.

The two enzymes of hepatocytolysis and their AST / ALT ratio, known as the de Ritis index, in addition to the additional indicators listed above, may indicate the causes of liver damage (hepatitis, gallstone disease, bile duct obstruction, liver cirrhosis, cirrhosis, etc.). .

The ALT test is prescribed for complaints such as:

Fatigue;
Nausea;
Loss of appetite;
Vomiting;
Discomfort in the stomach area;
Yellowing of the skin and eyes (jaundice).

Testing is performed in case of suspected acute hepatitis, as well as in contact with patients with acute viral hepatitis.

ALT is monitored regularly in patients with chronic hepatitis; Also in patients with cirrhosis of the liver, liver steatosis (fatty liver) and gallstone disease who are chronically abusing alcohol.

ALT is monitored for long-term use of medications that can damage the liver - e.g. Nonsteroidal anti-inflammatory drugs (NSAIDs), anticonvulsants, antipsychotics, certain antibiotics (eg clarithromycin), antifungals, immunomodulators, antihyperlipidemics and more.

The test is prescribed by a doctor.

Possible interpretation of the results

OTHER growing:

Acute viral and toxic hepatitis (drugs: carbon tetrachloride, acetaminophen);
In the case of acute hepatitis A, an increase in ALT precedes the development of jaundice by two weeks, with ALT values returning to normal after about 3 weeks;
Viral hepatitis B or C;
In chronic refractory hepatitis, transaminase levels increase periodically;
Chronic active hepatitis;

The increase in ALT during obstructive jaundice may be small and later; Rapid and noticeable increase (> 600 e / l), followed by a sharp decrease over 12-72 hours, is considered to be characteristic of acute bile duct obstruction;
In metastases to the liver, there is sometimes a moderate increase in ALT, while in primary hepatoma there are no noticeable changes in ALT levels;
In hepatic steatosis - ALT increases 2-3 times compared to normal;
ALT levels in liver cirrhosis are normal or slightly elevated (1-5 times higher than normal);
Moderate increases are also observed in alcoholic hepatitis, shock, severe burns, infectious mononucleosis, acute lymphoblastic leukemia (in children), myocardial infarction, heart failure, eclampsia, acute pancreatitis.

OTHER Decreases: