Macroprolactin | Laboratory research

SKU 957 Category

Additional information

Response time (working day) | Time to results


Location of analysis | Where is performed



Prolactin Presented in three different forms: the predominant monomeric form (80%), which is biologically and immunologically active; It is followed by the dimeric form - 5-20% ("big" prolactin), which is biologically inactive, and the tetrameric form - 0.5-5% ("big big" prolactin), with low biological activity.

Elevated serum prolactin levels may be associated with true With hyperprolactinemia (Increase in prolactin monomers) or may be prolactin dimers and polymers (Macroprolactinemia) Consequences of presence that are biologically inactive or have little activity (in case of laboratory hyperprolactinemia, without clinical manifestations) - This condition requires additional examination to rule out macroprolactin, as hyperprolactinemia, due to the presence of macroprolactin, usually does not require clinical treatment.

When should we take a test for macroprolactin?

  • Hyperprolactinemia in asymptomatic patients;
  • Hyperprolactinemia in the absence of evidence of pituitary damage.

How to prepare for the test?

Because prolactin concentrations vary at different times of the day, it is recommended that the test be performed in the morning, within 2 hours of waking up.

Blood should not be taken after a gynecological examination, physical exertion, stressful situations or breast stimulation. It is recommended to abstain from sexual intercourse and alcohol one day before the test.

Birth control pills, blood pressure medications, antidepressants can affect the results and should be discontinued as prescribed by your doctor.

Research material

Venous blood

Possible interpretation of the results

The results form shows the level of basal prolactin (quantification) and the qualitative indicator of macroprolactin: positive, borderline, negative.

Positive result:

Hyperprolactinemia is caused by the presence of a biologically inactive fraction of prolactin (Big-Big). Pituitary adenoma is not excluded.

Negative result:

Hyperprolactinemia is not caused by the presence of a biologically inactive fraction of prolactin (big-big). Looking for other causes of hyperprolactinemia.

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