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The 11-deoxycortisol test is used to diagnose congenital adrenal hyperplasia. 11-deoxycortisol is a precursor to cortisol. Its level increases significantly with a significant increase in the concentration of adrenocorticotropic hormone (for example, in Cushing's syndrome, corticotropin-synthesizing tumors, etc.) or in the case of 11-beta-hydroxylase deficiency.
Pharmacological blockade of 11-beta-hydroxylase with metyrapone and against this background determination of 11-deoxycortisol in serum or determination of 17-ketosteroids in urine - used to determine hypothalamo-pituitary-adrenal connections, for differential diagnostics of Cushing's syndrome and others.
Referral norms
0-18 years: <344 ng/dL
>18 above: 10-79 ng/dL
Elevated serum 11-deoxycortisol in suspected congenital adrenal hyperplasia indicates a possible 11-beta-hydroxylase (enzyme) deficiency. However, in some patients, an increase in serum 11-deoxycortisol may not be detected. In a number of cases, an increase in serum 11-deoxycortisol concentration is observed only in response to stimulation with adrenocorticotropic hormone.
Material for examination: Venous blood
Warning: Ethyl alcohol, estrogens, barbiturates, valproic acid, phenytoin, exogenous glucocorticoids cause a change in the response to the metyrapine test.
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
48 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Dusheti, Kareli, New Gudauri.
Use the Synevo web platform to view results from anywhere and anytime
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30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2023, the Synevo Georgia network will include 3 clinical laboratories and 47 blood sampling units, which will perform more than 300,000 tests.
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