Transglutaminase | Autoantibodies IgG

General Information

The study of tissue transglutaminase antibodies is an effective method for diagnosing celiac disease.

Celiac disease is a chronic autoimmune disorder that affects the digestive system. The starting mechanism of the process is the intake of food containing gluten (gluten is a protein found in cereals). The immune system produces antibodies against gluten. The immune response damages the small intestine. Celiac disease is different from gluten sensitivity and wheat intolerance. The chronic immune inflammatory reaction disrupts the digestive processes in the intestine, which prevents the assimilation of food nutrients.

Symptoms

Bloating

Diarrhea

Constipation

Flatulence

Nausea-vomiting

stomach-ache

Violation of tolerance to lactose

Rash

In children with celiac disease, the growth and development process is delayed, puberty is delayed due to insufficient absorption of nutrients. Damage to the mucous membrane of the oral cavity - stomatitis - is also common.

Diagnosis
Along with anamnestic and clinical data, physical examination and instrumental-laboratory research data are important for the diagnostics of the disease.

The detection of tissue transglutaminase antibodies is an important criterion in the diagnostics of the disease. These are antibodies developed in response to gluten intake, which damage intestinal transglutaminase (this enzyme is involved in recovery processes at the cellular level). The tissue transglutaminase IgA test is a highly effective and sensitive test.

Material for examination: Venous blood

Preliminary preparation: before conducting the research necessary, for a person to take gluten-containing products for a certain period of time in order to develop an immune reaction. Otherwise, the research is uninformative.