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The study of tissue transglutaminase antibodies is an effective method for diagnosing celiac disease.
Celiac disease is a chronic autoimmune disorder that affects the digestive system. The starting mechanism of the process is the intake of food containing gluten (gluten is a protein found in cereals). The immune system produces antibodies against gluten. The immune response damages the small intestine. Celiac disease is different from gluten sensitivity and wheat intolerance. The chronic immune inflammatory reaction disrupts the digestive processes in the intestine, which prevents the assimilation of food nutrients.
Symptoms
Bloating
Diarrhea
Constipation
Flatulence
Nausea-vomiting
stomach-ache
Violation of tolerance to lactose
Rash
In children with celiac disease, the growth and development process is delayed, puberty is delayed due to insufficient absorption of nutrients. Damage to the mucous membrane of the oral cavity - stomatitis - is also common.
Diagnosis
Along with anamnestic and clinical data, physical examination and instrumental-laboratory research data are important for the diagnostics of the disease.
The detection of tissue transglutaminase antibodies is an important criterion in the diagnostics of the disease. These are antibodies developed in response to gluten intake, which damage intestinal transglutaminase (this enzyme is involved in recovery processes at the cellular level). The tissue transglutaminase IgA test is a highly effective and sensitive test.
Material for examination: Venous blood
Preliminary preparation: before conducting the research necessary, for a person to take gluten-containing products for a certain period of time in order to develop an immune reaction. Otherwise, the research is uninformative.
Testing process
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30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2024, the Synevo Georgia network will include 3 clinical laboratories and 53 blood sampling units, which will perform more than 300,000 tests.
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