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Systemic autoimmune rheumatic diseases are characterized by elevated levels of autoantibodies produced against intracellular proteins and nucleic acids (DNA, RNA). These are called autoantibodies Antinuclear Antibodies (ANA), Because they are directed mainly against nuclear antigens.
ENA extractable nuclear autoantibodies It is a part of antinuclear antibodies and is directed against different classes of nuclear proteins:
Anti-SS-A
Anti-SS-B
Anti-RNP
Anti-SM
Anti-SCL-70
Anti-JO-1
Anti-SS-A – The most commonly detected ENA antibody. It is associated with systemic lupus erythematosus, its subacute subcutaneous course, neonatal lupus, etc.
Anti-SS-B - It is a typical marker of autoimmune connective tissue diseases. It occurs in Sjogren's disease, scleroderma, myositis, systemic lupus erythematosus.
Anti-RNP - Autoantibodies against ribonucleoproteins. It occurs in 45% of patients with systemic lupus erythematosus, however, it is also characteristic of other connective tissue diseases: Sjogren's syndrome, scleroderma and polymyositis.
Anti-SM - Smith's autoantibodies are formed against small nuclear ribonucleoprotein - Smith, which consists of B, B1, D, E, G protein subunits. Smith's autoantibodies are typical of systemic lupus erythematosus and are present in 30% of patients.
Anti-SCL-70 - Autoantibodies are present in 20% of patients with systemic scleroderma and often indicate a poor clinical prognosis.
Anti-JO-1 - It is an autoantibody characteristic of myositis, which occurs in patients with idiopathic inflammatory myopathies. These antibodies are directed against histidyl transport RNA synthetase and inhibit histidyl attachment to transport RNA during protein synthesis.
It is often associated with a form of polymyositis and dermatomyositis with lung damage. The anti-JO-1 antibody titer correlates directly with disease activity.
When Let's hold on test extractable antinuclear on antibodies?
Food, water and other products are not affected by the test results.
Venous blood
Positive Result Confirms the presence of specific antibodies.
weak signal Indicates that the presence of autoantibodies is unclear and questionable. Depending on the patient's symptoms, the test may be repeated every 1-2 months.
Negative Result Indicates the absence of specific autoantibodies.
Testing process
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
48 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Dusheti, Kareli, New Gudauri.
Use the Synevo web platform to view results from anywhere and anytime
Use the Synevo web platform to view results from anywhere, anytime
From Monday to Saturday you can use the laboratory services at home.
☎️ Hotline: 239 38 33 or 239 40 65
577293008 (9:00-დან 17:00-მდე)
30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2023, the Synevo Georgia network will include 3 clinical laboratories and 47 blood sampling units, which will perform more than 300,000 tests.
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