Chlamydia trachomatis | Antibodies IgG

Chlamydia Is a gram-negative intracellular bacterium. The genus Chlamydia combines four species: C. trachomatis, C. pneumoniae, C. psitttaci and C. pecorum.

Recent classifications divide chlamydia into 4 families, the most important of which is the family Chlamydiaceae, which includes two genera:

• Genus Chlamydia - The most important representative is C. trachomatis;
• Genus Chlamydophila - C. pneumoniae, C. psittaci, C. pecorum, C. abortus and others.

Of them important, Chlamydia trachomatisCan cause various diseases.

Serotypes of Chlamydia trachomatis - A, B and C. - They invite Trachoma - A serious disease that damages the eyes, causes severe conjunctivitis and increases the risk of vision loss. Trachoma is the most common cause of acquired blindness in the world. Transmission occurs through direct and contact with the infected eye or nasal secretions.

Serotype of Chlamydia trachomatis DK - Causes urinary tract infections.

Infections caused by Chlamydia trachomatis in women cause inflammation of the cervix, urethra, fallopian tubes, and uterus; In men - inflammation of the urethra, epididymis and prostate. It can also cause proctitis (inflammation of the rectum).

The infection is often asymptomatic, which hinders the process of receiving medical care and increases the risk of transmission to a partner during sexual intercourse. In some cases of infection may be mucous or mucous-purulent vaginal discharge, bleeding after intercourse, pain during urination, frequent urination and pain during intercourse. Infection can lead to complications such as infertility, reactive arthritis (part of Reiter's syndrome, along with conjunctivitis and urethritis), pelvic inflammatory disease, chronic pelvic pain, and ectopic pregnancy.

Chlamydia trachomatis is transmitted through sexual contact. Newborns of mothers with chlamydial infection may develop neonatal conjunctivitis, pneumonia and others.

Serotypes of Chlamydia trachomatis - L1-L3 - They invite Venereal lymphogranuloma - A disease characterized by painless genital ulcers that occur spontaneously. After a few weeks, the lymph nodes in the uterus, which may be swollen, increase in size.

The disease can cause infertility.

It is mainly found in tropical countries.

Chlamydial infections are treated with antimicrobials of macrolides, tetracyclines, and quinolones. Untreated chlamydial infection can lead to severe complications.

Serological, molecular-biological and other research methods are used to diagnose infections caused by Chlamydia trachomatis.

During serological examination, the following serological markers are identified - IgA, IgM and IgG antibodies.

IgG antibodies. 2-3 weeks after infection, IgG antibodies specific for Chlamydia trachomatis are detected in the blood and its persistence in the body lasts for many years, indicating infection with this pathogen. However, in order to determine patient management tactics (treatment decision, determination of etiology of clinical manifestations), the results of IgG determination must be compared with both clinical manifestations and anamnesis and data in the direct detection of the pathogen in the biological material studied by PCR. In case of negative results of PCR diagnostics, additional examination is necessary. In addition, it is incorrect to use dynamics of IgG antibody levels to monitor the effectiveness of treatment. IgG dynamics (4-fold increase) can be used to make an etiologic diagnostics, especially in the case of invasive forms of chlamydial infection.

When should we test for chlamydia against trachomatis IgG?

IgG antibodies are defined as:

• Among other markers, confirmation of infection caused by Chlamydia trachomatis at the clinic of cervicitis, salpingitis, endometritis (in women), epididymitis (in men), urethritis, proctitis, Reiter syndrome, arthritis, conjunctivitis, trachoma;
• In all cases of infertility (men and women);
• In infants and children in the first month of life with conjunctivitis and pneumonia;
• Assess the presence of infection when planning a pregnancy, assessing the risks of intrauterine infection of the fetus during pregnancy, and infecting the baby during childbirth.

How to prepare for the test?

No special preparation is required for the test.

Research material

Venous blood

Possible interpretation of the results

Positive result:

To assess the activity of the infectious process, it is necessary to use a direct method of microorganism detection - PCR (PCR).

Negative result:

• No infection is noted;
• Early stage of primary infection.

Resources

https://www.synevo.ro/shop/chlamydia-trachomatis-anticorpi-ig-g/

https://www.synevo.bg/chlamydia-trachomatis/

https://spravochnik.synevo.ua/ru/urogenitalnie-infektcii/id1093.html