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Estriol (E3) Is estrogen present in the blood and urine of a pregnant woman. Circulating estriol (90%) is produced in the placenta from DHEA (dehydroepiandrosterone), which is synthesized in the adrenal glands of the fetus and converted to estriol by the fetal liver and placenta.
Accordingly, estriol levels are a marker for fetal chromosomal pathology (included in the complex of second-trimester biochemical tests with AFP and β-hCG), and for assessing the condition of the fetus and fetoplacental complex. (With placental lactogen levels).
Prenatal biochemical screening - a marker of chromosomal pathology of the fetus (II trimester).
Fetal and fetoplacental complex condition marker:
Significant drop (less than 0.01 MoM):
Circulating estriol is mainly present in the conjugated form, which is excreted in the urine, with free estriol (unconjugated) accounting for about 9% of the total. Under normal conditions of fetal development, estriol production gradually increases, reaching a maximum at 36 weeks of gestation (pregnancy), however, significant individual fluctuations in levels are noted, so it is recommended to focus not on one-time determination of hormones but on the dynamics of hormone levels.
Low estriol levels, degenerative dynamics, or a sharp drop in levels indicate the presence of fetal pathology (chromosomal pathology, fetal intrauterine growth retardation, fetal adrenal pathology) or fetoplacental abnormalities (expected).
The combined determination of unconjugated estriol (E3), chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) in the second trimester of pregnancy is a study known as the "triple test". In addition to maternal clinical data and data from other studies, it is used as a screening study to assess the risk of chromosomal abnormalities in the fetus and is included in a set of biochemical markers.
The test must be performed On an empty stomach (On an empty stomach). The patient should indicate the date of the last menstrual period or the gestational (pregnancy) age determined by the ultrasound.
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