The site is temporarily down due to maintenance. Sorry for the inconvenience.
The site is temporarily down due to maintenance. Sorry for the inconvenience.
Quality & Accuracy
Experience
The latest technologies
Speed &
Credibility
₾175.00
Proinsulin It is synthesized in the β cells of the pancreas and in this way an insulin supply is created. It is actually an insulin precursor molecule, which in turn is the most important regulator of carbohydrate metabolism and ensures the uptake of glucose by cells.
Most of the synthesized proinsulin is broken down into insulin and C-peptide, which are secreted into the blood in equal amounts. About 15% of proinsulin enters the bloodstream in unchanged form. Like insulin and C-peptide, blood proinsulin reflects the condition of pancreatic β-cells. Proinsulin level measurement is used in the diagnostics of pancreatic β-cell tumors (insulinoma). Most insulinomas show an increase in the concentration of insulin, C-peptide and proinsulin, but in rare cases only an increase in proinsulin levels may be observed.
Proinsulin has a much lower biological activity (approximately 1:10) and a longer half-life (approximately 3: 1) than insulin. Despite the low biological activity of proinsulin, an isolated increase in its level can lead to hypoglycemic conditions, in malignantly transformed β cells, the ratio of synthesized hormones is shifted to proinsulin. In insulinomas, the proinsulin / insulin ratio is over 25%, sometimes up to 90%. Elevated concentrations of proinsulin may be observed in patients with renal insufficiency, cirrhosis, hyperthyroidism.
Proinsulin levels may increase significantly during PC1 / 3 convertase deficiency. In this case, the metabolism of peptide hormones is altered. People with deficiency of this enzyme, regardless of race, are characterized by red hair, obesity, infertility, adrenal insufficiency, low blood insulin levels, and cortisol deficiency.
PC 1/3 marker of insulinoma, enzyme convertase deficiency:
A test is required on empty stomach .
Venous blood
Proinsulin levels are elevated:
Elevated proinsulin levels indicate a far-reaching state of pancreatic beta cell depletion and represent a highly specific marker for insulin resistance.
It can be used as a therapy selection marker for type 2 diabetes: medications that stimulate insulin secretion, substances that increase tissue sensitivity to insulin (insulin sensitizers), or insulin therapy.
Proinsulin levels are impaired:
Testing process
Purchase a test |
Submission of material |
Results Online |
Consult a doctor |
More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
48 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Dusheti, Kareli, New Gudauri.
Use the Synevo web platform to view results from anywhere and anytime
Use the Synevo web platform to view results from anywhere, anytime
From Monday to Saturday you can use the laboratory services at home.
☎️ Hotline: 239 38 33 or 239 40 65
577293008 (9:00-დან 17:00-მდე)
30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2023, the Synevo Georgia network will include 3 clinical laboratories and 47 blood sampling units, which will perform more than 300,000 tests.
Contact information
Address: Tsinandali St. N9 (N1 Clinical Hospital area)
2021 – 2023 © Synevo. all rights reserved