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Ammonia is the main product of catabolism (breakdown) of ammonium acids. Ammonia is produced as a result of the breakdown of protein under the influence of bacteria in the intestine. The liver converts ammonia into urea, which is excreted in the urine. Excretion of ammonia from the blood is a vital process because it disrupts the acid-base balance of the blood and the functioning of the central nervous system.
At physiological pH, ammonia is almost completely ionized (NH4 + ).
Hyperammonemia, that is, an increase in the level of ammonia in the blood, is caused by the disruption of nitrogen metabolism in the liver.
When is the survey conducted?
Patient preparation
The study is conducted on an empty stomach. It is advisable to limit tobacco consumption for a few hours before sampling. It is necessary to inform the doctor about the medicines you are taking. Antibiotics often cause a decrease in ammonia levels.
Note: The blood sample must be transported frozen within 2 hours of collection. In the regions, nitrogen research is not done in the blood sample.
Referral norms:
Female: 11-51 nmol/l
Man: 16-60 nmol/l
Interpretation of results
Hyperammonemia That is, an increase in the concentration of ammonia in the blood serum characterizes the following conditions:
Ammonia concentration in blood serum decline It is characterized by hyperornithineemia – a condition caused by deficiency of ornithine aminotransferase. Damage to the vascular layer of the eye and the retina develops.
Ammonia levels vary according to the amount of protein consumed. Physical exertion may cause its temporary increase.
Elevated ammonia levels are caused by the liver enzyme gamma-glutamyl-transferase (GGT). increase in activity. Tightening the cuff during blood sampling may give a false hyperammonemia result.
Hemolysis causes a false increase in ammonia concentration, because the concentration of ammonia in erythrocytes is 3 times higher than its content in plasma.
Medicines that increase nitrogen levels in the blood:
Acetazolamide, asparaginase, chlorthalidone, ethacrynic acid, valproic acid, felbamate, furosemide, hydroflumethiazide, isoniazid, thiazides.
Medicines that reduce nitrogen levels in the blood:
Cefotaxime, diphenhydramine, kanamycin, lactobacilli, levodopa, MAO-inhibitors, neomycin, tetracycline, tromethamine.
Testing process
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
48 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Dusheti, Kareli, New Gudauri.
Use the Synevo web platform to view results from anywhere and anytime
Use the Synevo web platform to view results from anywhere, anytime
From Monday to Saturday you can use the laboratory services at home.
☎️ Hotline: 239 38 33 or 239 40 65
577293008 (9:00-დან 17:00-მდე)
30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2023, the Synevo Georgia network will include 3 clinical laboratories and 47 blood sampling units, which will perform more than 300,000 tests.
Contact information
Address: Tsinandali St. N9 (N1 Clinical Hospital area)
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