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Neisseria gonorrhea | DNA (PJR in real time)

Known as: Neisseria gonorrhoeae, gonorrhea
SKU: 1677

90.00

Study material: urine, urogenital smear
Response time (working days): 1 ****
The test is done on an empty stomach: no
Home call service: No.
Country: Georgia

General Information

**** Test is done once a week - Friday

Gonococcal infection (gonorrhea) Is Sexually transmitted diseaseCaused by Gram-negative bacteria - Neisseria gonorrhoeae. In Europe, gonorrhea is the second most common (after chlamydial infection), but its true prevalence is unknown due to the relatively high percentage of asymptomatic forms. It is known that the diagnostics of gonorrhea is 3 times more common in men than in women (this is partly due to a clearer clinical picture and timely diagnostics).

The main route of transmission is sexual contact, in rare cases transmission is possible through personal hygiene and intranatally, through the birth canal.

Currently, the most common method of diagnosing gonococcal infection remains the method of molecular diagnostics - polymerase chain reaction (PCR). This method allows the identification and appointment of treatment for N. gonorrhoeae in a short time with high diagnostic sensitivity and specificity (more than 96%).

When should we take the test?

  • Exclusion of Neisseria gonorrhoeae as a clinical cause of urethritis, vaginitis, cervicitis in women;
  • Exclusion of Neisseria gonorrhoeae as a clinical cause of urethritis, epididymitis, orchitis in men;
  • Exclusion of Neisseria gonorrhoeae at the diagnostics of trichomoniasis and other STDs;
  • Exclusion of Neisseria gonorrhoeae in all cases of infertility (men and women);
  • The presence of conjunctivitis in the newborn involves examination of both the newborn and the mother;
  • Conjunctivitis in adults;
  • Proctitis Clinic;
  • Pharyngitis of unknown etiology;
  • Monitor the effectiveness of treatment (no earlier than 3 weeks after the end of treatment).

In men with symptoms such as:

  • Burning and discomfort when urinating, redness;
  • Pain, heaviness and discomfort in the testicles;
  • Genital discharge.

In women with symptoms such as:

  • Pain when urinating;
  • Vaginal discharge;
  • Bleeding after intercourse, as well as between regular menstrual periods;
  • Abdominal and pelvic pain;

Possible interpretation of the results

The study material identified Neisseria gonorrhoeae:

Neisseria gonorrhoeae is the etiological cause of clinical manifestations.

The study material does not reveal Neisseria gonorrhoeae:

  • Infection is not noted;
  • Neisseria gonorrhoeae cannot be detected in the study material;
  • Small amount of pathogen (its level is below analytical susceptibility);
  • False-negative result in the presence of PCR test inhibitors in the study material.

Additional information

Neisseria gonorrhoeae is characterized by tropism of the vagina, urethra, endocervical canal, rectum, larynx, conjunctival epithelium. Bacteremia (less than 1% of cases) can lead to peritoneal inflammation. Transmission of the infection asymptomatic, which contributes to the development of complications due to lack of treatment, is typical for 50-90% of women and 10% of men. It should be noted that Neisseria gonorrhoeae are associated with an increased risk of developing other sexually transmitted infections, especially T. vaginalis.

The main manifestation of gonococcal infection in men is urethritis, which can lead to the development of the following complications: prostatitis, vesiculitis, epididymitis, paraurethritis, periurethritis, etc. Infertility may develop.

In women, according to the localization of the inflammatory process, there are:

  • Gonococcal infection of the lower parts of the genitourinary system (cervicitis, urethritis, cystitis, vulvovaginitis);
  • Inflammatory diseases of the pelvic organs (endometritis, salpingitis, oophoritis, pelvic peritonitis).

In case of chronic process and prolonged course of treatment, ectopic pregnancy and infertility may develop. Gonococcal infection in pregnant women causes premature rupture of membranes, premature birth, and fetal infection.

Other localizations of the lesion (in both men and women):

  • Anorectal zone;
  • Oropharynx;
  • Eye: Gonococcal ophthalmia in newborns, gonococcal conjunctivitis (gonoblenorea) usually occurs in newborns in the first hours or days of life. Infection develops when the fetus passes through the mother's infected birth canal or (in rare cases) comes into contact with the infant's maternity staff with infected hands.

Laboratory diagnostics of diseases caused by Neisseria gonorrhoeae includes direct detection methods such as microscopic examination of stained smear, culture method by inoculation with special means, and pjr (PCR) Diagnosis (detection of pathogen DNA).

Currently, the most common method of diagnosing gonococcal infection remains the method of molecular diagnostics - polymerase chain reaction (PCR). This method allows the identification and appointment of treatment for N. gonorrhoeae in a short time with high diagnostic sensitivity and specificity (more than 96%).

Research material

Recommended for PCR diagnostics:

  • In men The first part of the morning urine Use. This is the most optimal material in which case the diagnostic sensitivity reaches 85% -95%.
  • Consumption of the first part of urine in women has a lower diagnostic sensitivity (about 80-90%) than in men, so in the case of women Urogenital smear Recognized as the most optimal material for testing. The study of the first part of the urine in women can be used in situations where it is difficult to take a smear from the vagina and cervix (for example, in pregnant women) or in the face of a cystitis clinic (including chronic). It is the most optimal time to examine women The fourth week from the first day of the last menstrual period.

The research material should be brought to the laboratory by 13:00.

How to prepare for the test?

Before smearing:

  • Do not use a vaginal shower;
  • It is recommended to abstain from sexual intercourse for at least 24-48 hours;
  • Do not urinate directly before smearing;
  • Contraceptive use should be discontinued three days in advance;
  • The smear is taken 24-48 hours after the colposcopy and 24 hours after the vaginal ultrasound examination;

 

  • Perform external genital hygiene procedures without the use of soap and other detergents;
  • The test may be performed no earlier than 10-14 days after completion of antibacterial, antifungal, or topical antiseptics;
  • It is recommended to perform the test during ovulation or in the presence of symptoms of inflammatory disease of the urogenital tract.
  • No examination is performed during menstrual bleeding.
  • The study is conducted 2 weeks after taking preparations containing microorganisms (probiotics, eubiotoc).

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