The site is temporarily down due to maintenance. Sorry for the inconvenience.
The site is temporarily down due to maintenance. Sorry for the inconvenience.
Quality & Accuracy
Experience
The latest technologies
Speed &
Credibility
₾60.00
Determination of free erythrocyte protoporphyrins is recommended in the diagnostics of erythrocyte protoporphyria and X-linked protoporphyria.
Protoporphyrias are disorders caused by genetic defects in heme-synthesizing enzymes in the erythrocyte. Depending on which enzyme deficiency is expressed, different porphyrins and their precursors accumulate in different ways. Depending on which porphyrin accumulates in the erythrocyte and which heme precursors are excreted in the urine, different types of porphyrias are distinguished.
Determination of erythrocyte porphyrin levels is very sensitive in patients with a presumptive diagnostics of erythrocyte or X-linked protoporphyria. The clinical manifestations of both these porphyrias are the same
Iron deficiency in the body inhibits the terminal processes of heme synthesis and causes the accumulation of free erythrocyte protoporphyrins in erythrocyte progenitor cells. The cellular contents remain unchanged throughout the life of the erythrocyte. The function of free erythrocyte protoporphyrins is iron binding in the process of erythrocyte formation. The concentration of free erythrocyte protoporphyrins is increased during lead intoxication. The level of free erythrocyte protoporphyrins is also elevated in the diagnostics of erythrocyte protoporphyria and X-linked protoporphyria. Both of them are genetic photodermatoses caused by a deficiency of heme-synthesizing enzymes.
Erythrocytic protoporphyria develops in partial deficiency of the enzyme ferrochelatase. And X-linked protoporphyria is the result of a mutation in the ALAS2 gene. In both cases, erythrocyte protoporphyrins, which are released from the liver and blood vessel endothelium, accumulate in the blood plasma. When exposed to sunlight, protoporphyrins are activated and cause tissue damage and pain syndrome.
Patient preparation – 24 hours before taking the sample, alcohol intake is prohibited
Research material – Venous blood
Referral norm: <20 mcg/dL
Alcohol suppresses the activity of enzymes, which may cause a false positive result.
Testing process
Purchase a test |
Submission of material |
Results Online |
Consult a doctor |
More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
48 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Dusheti, Kareli, New Gudauri.
Use the Synevo web platform to view results from anywhere and anytime
Use the Synevo web platform to view results from anywhere, anytime
From Monday to Saturday you can use the laboratory services at home.
☎️ Hotline: 239 38 33 or 239 40 65
577293008 (9:00-დან 17:00-მდე)
30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2023, the Synevo Georgia network will include 3 clinical laboratories and 47 blood sampling units, which will perform more than 300,000 tests.
Contact information
Address: Tsinandali St. N9 (N1 Clinical Hospital area)
2021 – 2023 © Synevo. all rights reserved