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Study material: Venous blood
Response time (working day): 14
The test is done on an empty stomach: Yes
Home call service: YesPlasminogen activator is a protein through which tissue and other plasminogen are converted to plasmin. Plasmin, in turn, participates in fibrinolysis - the process of breaking down fibrin. By inhibiting (blocking) plasminogen activators, fibrinolysis is inhibited, which protects the body from bleeding.
In addition to participating in hemostasis, it is assumed that PAI-1 protein is involved in the processes of cell migration and tissue renewal.
The gene SERPINE1 ensures the synthesis of the protein - plasminogen activator inhibitor-1 (PAI-1). At least three mutations of the SERPINE1 gene have been found in people with PAI-1 protein deficiency. PAI-1 protein deficiency leads to the development of pathological bleeding. In such people, bleeding from any wound is extremely profuse and prolonged, which can be life-threatening.
A mutation in the SERPINE1 gene causes a deficiency of the plasminogen activator inhibitor-1 protein or the synthesis of an inactive form of the protein.
PAI-1 is a primary inhibitor of other tissue and blood plasminogen activators. Plasminogen activator inhibitor-1 limits fibrinolysis. Uncontrolled production of plasmin would lead to uncontrolled fibrin breakdown and increased risk of bleeding.
PAI-1 levels are regulated at the gene level. Possible changes in its coding gene are associated with changes in the concentration of plasminogen activator inhibitor. Elevated PAI-1 concentrations are associated with a number of atherosclerotic risk factors.
Insulin and proinsulin bind to PAI-1. Patients with diabetes and insulin resistance have elevated PAI-1 concentrations. PAI-1 also plays a thrombogenic role in both arterial and venous thromboembolic diseases.
An increase in PAI-1 concentration is also associated with the development of acute coronary syndrome, as well as the development of chronic coronary disease and coronary restenosis.
Molecular genetic testing may include both single gene testing and multigene panel studies.
Material for examination: Blood plasma, frozen
Plasminogen activator inhibitor-1 participates in normal blood clotting process - hemostasis. After the integrity of the blood vessel is broken, clots cover the damaged surface and protect the body from the progression of bleeding.
Plasminogen activator inhibitor-1 (PAI-1) belongs to a family of proteins that block plasminogen activators.
PAI-1 is a single-chain glycoprotein with a molecular weight of 47 kilodaltons. During fibrinolysis, inactive tissue plasminogen is converted into plasmin. Plasmin, in turn, plays an important role in fibrinolysis (dissolving fibrin) through fibrin degradation and activates the function of local proteases in a number of physiological processes, such as: ovulation, cell migration and epithelial cell differentiation.
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
48 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Dusheti, Kareli, New Gudauri.
Use the Synevo web platform to view results from anywhere and anytime
Use the Synevo web platform to view results from anywhere, anytime
From Monday to Saturday you can use the laboratory services at home.
☎️ Hotline: 239 38 33 or 239 40 65
577293008 (9:00-დან 17:00-მდე)
30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2023, the Synevo Georgia network will include 3 clinical laboratories and 47 blood sampling units, which will perform more than 300,000 tests.
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Address: Tsinandali St. N9 (N1 Clinical Hospital area)
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