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Activated Partial Thromboplastin Time (APTT)

Known as: Activated Partial Thromboplastin Time (APTT)
SKU: 1101


Study material: Venous blood
Response time (working days): 1 ****
The test is done on an empty stomach: Yes
Home call service: Yes
Country: Georgia

General Information

Coagulation is a process that takes place in the body to prevent excessive bleeding. However, the circulating blood in your blood vessels should not normally clot. If a blood clot forms and clots can form, a blood clot can travel through your bloodstream to your heart, lungs, or brain, causing a heart attack, stroke, or even death.

Coagulation tests determine the ability of a blood to clot and the time it takes to clot. Testing will help your doctor assess the risk of developing excessive bleeding or thrombosis.

When should we take the test?

  • Control and monitoring of therapy with non-fractional heparin and thrombin inhibitors (hirudin, argatroban).
  • Diagnosis of congenital or acquired failure of certain coagulation factors (XII, XI, IX, VIII, VII), suspicion of hemophilia or von Willebrand disease.
  • Determine the presence of specific or nonspecific coagulation inhibitors (lupus anticoagulant, antiphospholipid antibodies).

The test is recommended in conjunction with other tests included in coagulation profiles

  • Annual prophylactic examinations In order. The frequency of coagulation test for prophylaxis depends on the age of the patient: for young people it is recommended once a year, for the elderly - once every 6 months.
  • See also When infected with SARS-CoV-2, To prevent thrombosis.

The examination is prescribed by a doctor.

Possible interpretation of the results

The extension of aPTT is related to:

  • All congenital deficits (including hemophilia A and B, von Willebrand disease);
  • Thrombin inhibitors (hirudin, argatroban);
  • Streptokinase;
  • Urokinase;
  • Oral anticoagulant therapy;
  • Vitamin K deficiency;
  • Malnutrition;
  • Intravascular coagulation syndrome;
  • The presence of fibrin degradation products;
  • The presence of circulating factor-specific anticoagulants;
  • Nonspecific - Lupus anticoagulants.
  • Normal PT (prothrombin time), prolonged aPTT: Deficiency of precalicrin or one of VIII, IX, XI and / or XII factors is likely.
  • Prolonged PT, normal aPTT: Possible factor VII deficiency. Nutritional or therapeutic deficiency of vitamin K-dependent factors can sometimes lead to prolonged PT and normal aPTT.
  • Prolonged PT and aPTT: Deficiency of factor I, II, V or X is likely.

The reduction in aPTT is related to:

  • Increased levels of one factor, most often factor VIII;
  • Common neoplasms (except when the liver is damaged);
  • Severe bleeding;
  • Early stage of DIC.

Prolonged aPTT indicates hemorrhagic disease, while reduced aPTT has been found to be an independent predictor of death at high risk of thrombosis and bleeding.

aPTT depends on the age of the patient: in infants the upper limit of aPTT extends to 55 s and gradually decreases to the adult level by 6 months; Prolonged values ​​of aPTT in healthy children are caused by a mild deficiency of several coagulation proteins. Even in the elderly aPTT may be reduced.

Additional information

Activated partial thromboplastin time (aPTT) The study is a functional test that provides important information about the functioning of the coagulation system and certain factors.

This indicator is most commonly used to control and monitor therapy with non-fractional heparin and thrombin inhibitors (hirudin, argatroban). However, aPTT is not a first-line indicator when evaluating heparin treatment.

The test is also used to diagnose congenital or acquired insufficiency of certain coagulation factors (XII, XI, IX, VIII, VII) in case of suspected hemophilia or von Willebrand disease.

The aPTT test is used to detect the presence of specific or nonspecific coagulation inhibitors in the body - for example, lupus anticoagulant and antiphospholipid antibodies that are associated with clinical manifestations such as thrombosis.

It is also used as an indicator to assess the risk of bleeding before surgery.

How to prepare for the test?

Blood sampling for analysis is necessary without fasting, without taking medication for the last 12 hours. The patient should be informed whether he or she is taking medications that affect blood clotting.

If you are taking blood thinners, consult your doctor about your examination.

If heparin therapy is required to be monitored, test material should be obtained from a non-heparinized source one hour prior to the next heparin administration.

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