Antistreptolysin O (ASLO)

Streptolysin Is hemolysin, which is produced by group A streptococci. In infected patients, streptolysin acts as an antigen against which the body produces specific antibodies. An increase in the concentration of antistreptolytic antibodies indicates the sensitization of the body to streptococcal antigens. The increase in ASL-O concentration starts within 1 week after the detection of streptococcal infection and its level reaches a maximum in 2-4 weeks. In the absence of complications or recurrence of infection, ASL-O levels return to normal after 6-12 months. ASL-O (antistreptolysin-O) Constant increase in the level increases the risk of developing complications of rheumatism. During the recovery period the rate decreases compared to the acute period. Serial examination (at intervals of about 1-2 weeks) has maximum diagnostic and prognostic value. ASL-O titers may also be elevated in healthy carriers of streptococci.

When to take an antistreptolysin O test?

• Confirmation of the effect of streptococcal streptolysin;
• Diagnosis of conditions associated with streptococcal infections: acute rheumatoid arthritis, glomerulonephritis, endocarditis, scarlet fever;
• Regular monitoring of patients with acute rheumatoid arthritis (every 2-4 weeks).

How to prepare for the test?

The test should be performed on an empty stomach.

Research material

Venous blood

Possible interpretation of the results

Concentrations of antistreptolysin-O increase:

• Rheumatism;
• Streptococcal infections;
• Acute diffuse glomerulonephritis.

Resources

https://spravochnik.synevo.ua/ru/klinicheskaia-himia/antistreptolysin-o.html