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Follicle-stimulating hormone (FSH)

Known as: follicle-stimulating hormone
SKU: 1014


Study material: Venous blood
Response time (working day): 1-2
The test is done on an empty stomach: no
Home call service: Yes
Country: Georgia

General Information

Follicle-stimulating hormone (FSH) Together with melatoninizing hormone (LH) it belongs to the family of gonadotropic hormones. They are synthesized in the anterior pituitary gland under the influence of gonadotropin-releasing hormone from the hypothalamus. The level of gonadotropic hormones in the blood is controlled by the principle of the effect of sex hormones (estrogen, progesterone, testosterone, etc.) on the hypothalamus.

When should we take the test?

In men: Identification of hypothalamic-pituitary-gonadal dysfunction (mainly to make a differential diagnostics between primary testicular failure and stimulation deficiency), genetic disorders by chromosomal aberrations (e.g., Kleinfelter syndrome), testicular dysfunction, testicular dysfunction.

In women: Detection of hypothalamic-pituitary-gonadal dysfunction (mainly to make a differential diagnostics between primary ovarian failure and ovarian stimulation deficiency), polycystic ovaries, menstrual disorders (including amenorrhea), assessment of menstrual cycle phases, assessment of menstrual cycle phases. FSH can be checked for symptoms of premature ovarian failure: irregular or absent menstrual cycle, inability to conceive, urination and night sweats, weight gain, easy fatigue, frequent headaches, insomnia. The test is also recommended in case of questionable infertility in both sexes. In such cases, it is recommended that the test be performed in conjunction with other tests such as LH, estrogen, and testosterone.

Possible interpretation of the results

Primary hypogonadism causes an increase in FSH and LH.

FSH also increases:

  • Gonadal dysfunction;
  • During menopause (often more than 40 IU / L);
  • Ovarian hypofunction in women;
  • Decrease in ovarian reserve;
  • Hypogonadism in men;
  • Testicular feminization syndrome in men.

Normal or impaired FSH may be noted in polycystic ovary syndrome. In this condition, an increase in basal LH levels and chronic anovulation may be noted.

Low FSH and LH may be a sign of decreased pituitary or hypothalamic function. Low levels of FSH are associated with decreased spermatogenesis and egg production.

Some drugs may affect FSH results: Taking bromocripine, clomiphene, erythropoietin, ketoconazole, levodopa, naloxone, and digitalis increases FSH levels.

In turn, medications that can lower FSH levels are: corticosteroids, estrogen, oral contraceptives. The use of these medications should be reported to your doctor.

Additional information

Follicle-stimulating hormone (FSH) And melatoninizing hormone (LH) levels increase when sex hormones are under-produced (hypogonadism, Kleinfelter syndrome, anorexia, testicular feminization, alcoholism, castration, menopause). FSH and LH levels are low in pituitary or hypothalamic insufficiency, tumors of the testicles or adrenal glands that affect the secretion of estrogens or androgens.

In men, FSH stimulates spermatogenesis (low levels of gonadotropic hormones can cause azoospermia).

In women, FSH, along with LH, stimulates follicle growth and maturation as well as estrogen biosynthesis at the follicle level. FSH levels are maximal in the middle of the menstrual cycle (ovulation phase), but with less increase than in the case of LH; Elevated levels of these hormones in the middle of the menstrual cycle divide it into two phases - follicular and luteal, each lasting about 14 days.


How to prepare for the test?

The material is taken in the first half of the day, in a calm state. Fatty foods, exercise, tobacco should be excluded one day before the examination. In women, the basal level of the hormone is determined in the first days (3-5) days of the menstrual cycle. When diagnosing a menstrual cycle disorder, it is advisable to determine the hormone several times at different phases of the cycle. The patient should indicate the date of the last menstrual period when taking the test.

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