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How to find out if we have an allergy or histamine intolerance? – Diamine oxidase test

08/07/2025

Allergy and histamine intolerance often present with identical symptoms.

How do we find out what we're dealing with? What research should we conduct?

Histamine is a biologically active mediator that is produced in our body in response to various allergens. We also get histamine from food and drink. The cause of histamine intolerance is a deficiency of the enzyme that breaks it down – diamine oxidase.

Diamine oxidase deficiency – leads to the accumulation of histamine in the body and the development of symptoms such as:

Migraine and other headache syndromes

Respiratory system disorders

Imbalance of sex hormones

Changes in the cardiovascular system

Bone and joint complaints

Digestive tract disorders and others

Determining diamine oxidase helps to diagnose histamine intolerance. Learn more about the study:

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